Journal: Annals of Translational Medicine

Article Title: A narrative review of intraocular lens opacifications: update 2020

doi: 10.21037/atm-20-4207

Figure Lengend Snippet: The summary of major original studies on glistenings

Article Snippet: A high amount of glistenings developed in most SN60WF IOLs, while only few ZCB00 IOLs displayed a low degree of glistenings Chang et al. ( 83 ) 80 patients: 40 AcrySof SA60AT (1-piece IOL group); 40 a Sensar AR40e (3-piece IOL group) 5 to 7 years postoperatively, retroillumination images were obtained and the PCO area and severity were evaluated using computer software There were no significant differences in PCO between the 2 groups High-contrast (100%) and low-contrast (2.5%) CDVA were measured The 3-piece IOL group had significantly fewer glistenings (P<0.001) Scheimpflug images were obtained to evaluate glistenings, which were quantified objectively by digital image analysis using computer software There was correlation between the subjective grading of glistenings and objective computer-processed image grading The glistenings were not correlated with IOL power, CDVA, or CS Thomes et al. ( 82 ) AcrySof Natural IOLs Model SB30 AL (n=100) manufactured in 2003 Glistenings were induced in vitro Glistenings were present in all lenses after the accelerated microvacuole test method AcrySof Natural IQ Model SN60 WF IOLs (n=270) manufactured in 2012 Image analysis program was used to evaluate glistenings The mean microvacuole density for IOLs manufactured in 2003 was 315.7 microvacuoles per square millimeter (MVs/mm 2 ) with a glistening severity less than 100 MVs/mm 2 in 1.0% of the IOLs The mean microvacuole density for IOLs manufactured in 2012 was 39.9 MVs/mm 2 with a glistening severity less than 100 MVs/mm 2 in 95.2% of the IOLs Laboratory-induced microvacuole density was significantly lower in IOLs manufactured in 2012 (mean 39.9 MVs/mm 2 ) relative to IOLs manufactured in 2003 (mean 315.7 MVs/mm 2 ) as indicated by the Wilcoxon test of significance (P<0.0005) Miyata et al. ( 35 ) 24 eyes received AcrySof SN60WF IOL before manufacturing improvement Light scattering on the anterior IOL surface was examined up to 3 years postoperatively using an EAS-1000 anterior segment analyzer After the improvement, the IOLs showed no increase in surface light scattering up to 2 years, a significant increase was found at 3 years (P<0.001) 27 eyes received AcrySof SN60WF IOL after improvement The CDVA and CS under photopic and mesopic conditions were also examined 3 years postoperatively The light scattering with the improved IOL was significantly reduced at all observations (P<0.048) No difference was found in the CDVA and CS van der Mooren et al. ( 84 ) 5 AcrySof IOLs (Alcon Laboratories Inc, Forth Worth, Texas, USA) Glistenings were induced in vitro .

Techniques: Control, Transmission Assay, Spectrophotometry, In Vitro, Derivative Assay, Incubation, Microscopy, Imaging, Software, Light Microscopy, Standard Deviation

Journal: Annals of Translational Medicine

Article Title: A narrative review of intraocular lens opacifications: update 2020

doi: 10.21037/atm-20-4207

Figure Lengend Snippet: The summary of risk factors for IOL glistenings and calcifications

Article Snippet: A high amount of glistenings developed in most SN60WF IOLs, while only few ZCB00 IOLs displayed a low degree of glistenings Chang et al. ( 83 ) 80 patients: 40 AcrySof SA60AT (1-piece IOL group); 40 a Sensar AR40e (3-piece IOL group) 5 to 7 years postoperatively, retroillumination images were obtained and the PCO area and severity were evaluated using computer software There were no significant differences in PCO between the 2 groups High-contrast (100%) and low-contrast (2.5%) CDVA were measured The 3-piece IOL group had significantly fewer glistenings (P<0.001) Scheimpflug images were obtained to evaluate glistenings, which were quantified objectively by digital image analysis using computer software There was correlation between the subjective grading of glistenings and objective computer-processed image grading The glistenings were not correlated with IOL power, CDVA, or CS Thomes et al. ( 82 ) AcrySof Natural IOLs Model SB30 AL (n=100) manufactured in 2003 Glistenings were induced in vitro Glistenings were present in all lenses after the accelerated microvacuole test method AcrySof Natural IQ Model SN60 WF IOLs (n=270) manufactured in 2012 Image analysis program was used to evaluate glistenings The mean microvacuole density for IOLs manufactured in 2003 was 315.7 microvacuoles per square millimeter (MVs/mm 2 ) with a glistening severity less than 100 MVs/mm 2 in 1.0% of the IOLs The mean microvacuole density for IOLs manufactured in 2012 was 39.9 MVs/mm 2 with a glistening severity less than 100 MVs/mm 2 in 95.2% of the IOLs Laboratory-induced microvacuole density was significantly lower in IOLs manufactured in 2012 (mean 39.9 MVs/mm 2 ) relative to IOLs manufactured in 2003 (mean 315.7 MVs/mm 2 ) as indicated by the Wilcoxon test of significance (P<0.0005) Miyata et al. ( 35 ) 24 eyes received AcrySof SN60WF IOL before manufacturing improvement Light scattering on the anterior IOL surface was examined up to 3 years postoperatively using an EAS-1000 anterior segment analyzer After the improvement, the IOLs showed no increase in surface light scattering up to 2 years, a significant increase was found at 3 years (P<0.001) 27 eyes received AcrySof SN60WF IOL after improvement The CDVA and CS under photopic and mesopic conditions were also examined 3 years postoperatively The light scattering with the improved IOL was significantly reduced at all observations (P<0.048) No difference was found in the CDVA and CS van der Mooren et al. ( 84 ) 5 AcrySof IOLs (Alcon Laboratories Inc, Forth Worth, Texas, USA) Glistenings were induced in vitro .

Techniques: Medications, Injection

Journal: Annals of Translational Medicine

Article Title: A narrative review of intraocular lens opacifications: update 2020

doi: 10.21037/atm-20-4207

Figure Lengend Snippet: The summary of studies evaluating the impact of IOL glistenings and calcifications on visual quality

Article Snippet: A high amount of glistenings developed in most SN60WF IOLs, while only few ZCB00 IOLs displayed a low degree of glistenings Chang et al. ( 83 ) 80 patients: 40 AcrySof SA60AT (1-piece IOL group); 40 a Sensar AR40e (3-piece IOL group) 5 to 7 years postoperatively, retroillumination images were obtained and the PCO area and severity were evaluated using computer software There were no significant differences in PCO between the 2 groups High-contrast (100%) and low-contrast (2.5%) CDVA were measured The 3-piece IOL group had significantly fewer glistenings (P<0.001) Scheimpflug images were obtained to evaluate glistenings, which were quantified objectively by digital image analysis using computer software There was correlation between the subjective grading of glistenings and objective computer-processed image grading The glistenings were not correlated with IOL power, CDVA, or CS Thomes et al. ( 82 ) AcrySof Natural IOLs Model SB30 AL (n=100) manufactured in 2003 Glistenings were induced in vitro Glistenings were present in all lenses after the accelerated microvacuole test method AcrySof Natural IQ Model SN60 WF IOLs (n=270) manufactured in 2012 Image analysis program was used to evaluate glistenings The mean microvacuole density for IOLs manufactured in 2003 was 315.7 microvacuoles per square millimeter (MVs/mm 2 ) with a glistening severity less than 100 MVs/mm 2 in 1.0% of the IOLs The mean microvacuole density for IOLs manufactured in 2012 was 39.9 MVs/mm 2 with a glistening severity less than 100 MVs/mm 2 in 95.2% of the IOLs Laboratory-induced microvacuole density was significantly lower in IOLs manufactured in 2012 (mean 39.9 MVs/mm 2 ) relative to IOLs manufactured in 2003 (mean 315.7 MVs/mm 2 ) as indicated by the Wilcoxon test of significance (P<0.0005) Miyata et al. ( 35 ) 24 eyes received AcrySof SN60WF IOL before manufacturing improvement Light scattering on the anterior IOL surface was examined up to 3 years postoperatively using an EAS-1000 anterior segment analyzer After the improvement, the IOLs showed no increase in surface light scattering up to 2 years, a significant increase was found at 3 years (P<0.001) 27 eyes received AcrySof SN60WF IOL after improvement The CDVA and CS under photopic and mesopic conditions were also examined 3 years postoperatively The light scattering with the improved IOL was significantly reduced at all observations (P<0.048) No difference was found in the CDVA and CS van der Mooren et al. ( 84 ) 5 AcrySof IOLs (Alcon Laboratories Inc, Forth Worth, Texas, USA) Glistenings were induced in vitro .

Techniques: Produced, Control

Journal: Indian Journal of Ophthalmology

Article Title: Incidence and causes of negative dysphotopsia after uncomplicated cataract surgery – A randomized clinical trial

doi: 10.4103/ijo.IJO_3751_20

Figure Lengend Snippet: Comparison of demographic and clinical characteristics of eyes with and without negative dysphotopsia

Article Snippet: All consenting patients were first randomized at the time of enrollment into two treatment groups based on the type of IOL to be placed: a hydrophobic acrylic IOL (Alcon Acrysof ® SN60WF) made of high index material (refractive index = 1.55), a 6-mm optic with a square edge optic design and C-loop haptics and a hydrophilic acrylic IOL (CT Asphina ® 603P, Carl Zeiss Meditec) with a 6-mm optic, square-edged optic design, refractive index of 1.46 and plate haptics.

Techniques:

Journal: Indian Journal of Ophthalmology

Article Title: Incidence and causes of negative dysphotopsia after uncomplicated cataract surgery – A randomized clinical trial

doi: 10.4103/ijo.IJO_3751_20

Figure Lengend Snippet: Comparison in clinical characteristics between two types of IOL and in between eyes that had and did not have wound hydration

Article Snippet: All consenting patients were first randomized at the time of enrollment into two treatment groups based on the type of IOL to be placed: a hydrophobic acrylic IOL (Alcon Acrysof ® SN60WF) made of high index material (refractive index = 1.55), a 6-mm optic with a square edge optic design and C-loop haptics and a hydrophilic acrylic IOL (CT Asphina ® 603P, Carl Zeiss Meditec) with a 6-mm optic, square-edged optic design, refractive index of 1.46 and plate haptics.

Techniques:

Journal: Indian Journal of Ophthalmology

Article Title: Incidence and causes of negative dysphotopsia after uncomplicated cataract surgery – A randomized clinical trial

doi: 10.4103/ijo.IJO_3751_20

Figure Lengend Snippet: Comparison in clinical characteristics between four groups with combinations of IOL type and hydration

Article Snippet: All consenting patients were first randomized at the time of enrollment into two treatment groups based on the type of IOL to be placed: a hydrophobic acrylic IOL (Alcon Acrysof ® SN60WF) made of high index material (refractive index = 1.55), a 6-mm optic with a square edge optic design and C-loop haptics and a hydrophilic acrylic IOL (CT Asphina ® 603P, Carl Zeiss Meditec) with a 6-mm optic, square-edged optic design, refractive index of 1.46 and plate haptics.

Techniques:

Journal: Indian Journal of Ophthalmology

Article Title: Incidence and causes of negative dysphotopsia after uncomplicated cataract surgery – A randomized clinical trial

doi: 10.4103/ijo.IJO_3751_20

Figure Lengend Snippet: Univariate and multivariable logistic regression analysis for factors associated with occurrence of negative dysphotopsia in our cohort ( n =29 eyes)

Article Snippet: All consenting patients were first randomized at the time of enrollment into two treatment groups based on the type of IOL to be placed: a hydrophobic acrylic IOL (Alcon Acrysof ® SN60WF) made of high index material (refractive index = 1.55), a 6-mm optic with a square edge optic design and C-loop haptics and a hydrophilic acrylic IOL (CT Asphina ® 603P, Carl Zeiss Meditec) with a 6-mm optic, square-edged optic design, refractive index of 1.46 and plate haptics.

Techniques: